Current Research Studies - Brain & Spine

The following list contains research studies in which the OSF Illinois Neurological Institute is enrolling participants.

For additional information on the research studies listed below, or to inquire about enrollment, contact the individual listed for the study.

Epilepsy

  • Use of Near-Infrared Spectroscopy to Investigate Periodic Electroencephalographic Discharges in Critically Ill Patients

  • Summary: The purpose of this study is to find new ways to detect seizure activity and understand the meaning of different patterns on electroencephalography (EEG). Researchers want to understand if near-infrared spectroscopy (NIRS), using an instrument similar to ultrasound to measure oxygen levels in the brain through the scalp, could help determine the meaning of different EEG patterns and assist the doctors in providing better care to patients who might be having seizures.

    Investigator: Michael Xu

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    Contact: Dawn Bolliger, 309-655-4727, Dawn.R.Bolliger@osfhealthcare.org

  • EP0091 - ARISE: pAdsevonil in drug-ResiStant Epilepsy : A Randomized, Double-Blind, Placebo-Controlled, Dose Finding Study to Evaluate the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-Onset Seizures in Adult Subjects with Drug-Resistant Epilepsy

  • Summary: The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset seizures in subjects with drug-resistant epilepsy.

    Investigator: Michael Xu

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov:  NCT02408523

    Contact: Dawn Bolliger, 309-655-4727, Dawn.R.Bolliger@osfhealthcare.org

Multiple Sclerosis

  • ESTEEM - A Multicenter, Global, Observational Study to Collect Information on Safety and to Document the Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in the Treatment of Multiple Sclerosis

  • Summary: The primary objective of the study is to determine the incidence, type, and pattern of side effects leading to treatment discontinuation in patients with multiple sclerosis treated with dimethyl fumarate (DMF).

    Investigator: Diana Londono

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov:  NCT02047097

    Contact: Christine Brown, 309-655-3448, Christine.S.Brown@osfhealthcare.org

  • PASSAGE - Long-term, Prospective,Multinational, Parallel-cohort Study Monitoring Safety in Patients With MS Newly Started With Fingolimod Once Daily or Treated With Another Approved Disease-modifying Therapy

  • Summary: The purpose of this study is to further explore the incidence of selected safety- related outcomes and to further monitor the overall safety profile of fingolimod under conditions of routine medical practice.

    Investigator: Diana Londono

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov:  NCT01442194

    Contact: Christine Brown, 309-655-3448, Christine.S.Brown@osfhealthcare.org

  • A Multicenter, Randomized, Double Blind, Placebo Controlled Parallel Group, Pilot Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in Subjects With Relapsing-remitting Multiple Sclerosis

  • Summary: This is a multiple dose study to estimate the response rate, and examine the safety of H.P. Acthar® Gel (Acthar) in subjects with RRMS who have not responded to high dose steroids. 

    Investigator: Diana Londono

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov:  NCT03126760

    Contact: Mary Buttice, 309-624-8401, Mary.C.Buttice@osfhealthcare.org

Neuro-Vestibular

  • AVERT - Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage

  • Summary: This study is comparing video-oculography (VOG)-guided care to standard care to assess accuracy of diagnoses and initial management decisions for emergency department (ED) patients with a chief symptom of vertigo or dizziness suspected to be of vestibular cause.

    Investigator: Jorge Kattah

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov:  NCT02483429

    Contact: Mary Buttice, 309-624-8401, Mary.C.Buttice@osfhealthcare.org

Stroke / Cerebrovascular

  • What are the characteristics of survivors and caregivers attending stroke camp?

  • Summary: This study is a descriptive survey of adult stroke survivors and stroke caregivers who have attended stroke camp to obtain demographic characteristics and effects of the stroke camp on perceptions of depression, isolation, and loneliness.

    Investigator: Maureen Mathews

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    Contact: Judi Beck, 309-624-3240, Judith.M.Beck@osfhealthcare.org

Movement Disorders

  • MSK-002: An Randomized, Placebo-controlled, Parallel Group Study to Evaluate the Effect of Amifampridine Phosphate in Patients with MuSK Antibody Positive Myasthenia Gravis, and a Sample of AChR Antibody Positive Myasthenia Gravis Patients

  • Summary: Efficacy and safety of amifampridine phosphate in improving the activities of daily living for patients with antibody positive MuSK myasthenia gravis.

    Investigator: Vahid Tohidi

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov:  NCT02408523

    Contact: Randall McClallen, 309-624-4087, Randall.B.McClallen@osfhealthcare.org