Neurosciences

Neurosciences

The following list contains research studies in which the OSF Illinois Neurological Institute is enrolling participants.

For additional information on the research studies listed below, or to inquire about enrollment, contact the individual listed for the study.

Healthy Volunteers

  • Y-2-001: A Single Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of Y-2 Sublingual Tablet in Healthy Subjects

  • Summary: The primary objective is to evaluate the safety and tolerability of single ascending dose of Y-2 sublingual tablets in healthy male and female adult subjects. The secondary objective is to characterize the single-dose pharmacokinetics of Y-2 sublingual tablets in healthy male and female adult subjects.

    Investigator: David Wang

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT03495206

    Contact: Complete the online Pre-Screening Form or contact Judi Beck, 309-624-3240, Judith.M.Beck@osfhealthcare.org

Epilepsy

  • A Double-blind, Randomized, Placebo-controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy and Safety of Lacosamide as Adjunctive Therapy for Uncontrolled Primary Generalized Tonic-Clonic Seizures in Subjects With Idiopathic Generalized Epilepsy

  • Summary: Evaluating efficacy & safety of lacosamide versus placebo in a blinded fashion as add-on therapy for primary generalized tonic-clonic (PGTC) seizures in subjects ≥4 years of age with idiopathic generalized epilepsy (IGE) currently taking 1 to 3 antiepileptic drugs.

    Investigator: Michael Xu

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT03495206

    Contact: Dawn Bolliger, 309-655-4727, Dawn.R.Bolliger@osfhealthcare.org

  • Use of Near-Infrared Spectroscopy to Investigate Periodic Electroencephalographic Discharges in Critically Ill Patients

  • Summary: The purpose of this study is to find new ways to detect seizure activity and understand the meaning of different patterns on electroencephalography (EEG). Researchers want to understand if near-infrared spectroscopy (NIRS), using an instrument similar to ultrasound to measure oxygen levels in the brain through the scalp, could help determine the meaning of different EEG patterns and assist the doctors in providing better care to patients who might be having seizures.

    Investigator: Michael Xu

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    Contact: Dawn Bolliger, 309-655-4727, Dawn.R.Bolliger@osfhealthcare.org

Multiple Sclerosis

  • PASS - A Prospective, Multicenter, Observational Post-Authorization Safety Study to Evaluate the Long Term Safety Profile of Lemtrada® (alemtuzumab) Treatment in Patients With Relapsing Forms of Multiple Sclerosis

  • Summary: The purpose of this observational study is to collect information about the long term safety of treatment with LEMTRADA® (alemtuzumab) in adult patients with relapsing multiple sclerosis in the course of routine clinical practice. 

    Investigator: Reuben Valenzuela

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    Contact: Mary Buttice, 309-624-8401, Mary.C.Buttice@osfhealthcare.org  

  • ESTEEM - A Multicenter, Global, Observational Study to Collect Information on Safety and to Document the Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in the Treatment of Multiple Sclerosis

  • Summary: The primary objective of the study is to determine the incidence, type, and pattern of side effects leading to treatment discontinuation in patients with multiple sclerosis treated with dimethyl fumarate (DMF).

    Investigator: Reuben Valenzuela

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT02047097

    Contact: Christine Brown, 309-655-3448, Christine.S.Brown@osfhealthcare.org

  • PASSAGE - Long-term, Prospective,Multinational, Parallel-cohort Study Monitoring Safety in Patients With MS Newly Started With Fingolimod Once Daily or Treated With Another Approved Disease-modifying Therapy

  • Summary: The purpose of this study is to further explore the incidence of selected safety- related outcomes and to further monitor the overall safety profile of fingolimod under conditions of routine medical practice.

    Investigator: Reuben Valenzuela

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT01442194

    Contact: Christine Brown, 309-655-3448, Christine.S.Brown@osfhealthcare.org

  • A Multicenter, Randomized, Double Blind, Placebo Controlled Parallel Group, Pilot Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in Subjects With Relapsing-remitting Multiple Sclerosis

  • Summary: This is a multiple dose study to estimate the response rate, and examine the safety of H.P. Acthar® Gel (Acthar) in subjects with RRMS who have not responded to high dose steroids. 

    Investigator: Reuben Valenzuela

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT03126760

    Contact: Mary Buttice, 309-624-8401, Mary.C.Buttice@osfhealthcare.org

Neuro-Vestibular

  • AVERT - Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage

  • Summary: This study is comparing video-oculography (VOG)-guided care to standard care to assess accuracy of diagnoses and initial management decisions for emergency department (ED) patients with a chief symptom of vertigo or dizziness suspected to be of vestibular cause.

    Investigator: Jorge Kattah

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT02483429

    Contact: Mary Buttice, 309-624-8401, Mary.C.Buttice@osfhealthcare.org

Stroke / Cerebrovascular

  • ENRICH - Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ICH)

  • Summary: This is a trial comparing standard medical management to early (<24 hours) surgical hematoma evacuation using minimally invasive parafascicular surgery (MIPS) in the treatment of acute spontaneous supratentorial intracerebral hemorrhage. 

    Investigator: Andrew Tsung

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT02880878

    Contact: Judi Beck, 309-624-3240, Judith.M.Beck@osfhealthcare.org

  • SETPOINT2 - Stroke-Related Early Tracheostomy Versus Prolonged Orotracheal Intubation in Neurocritical Care Trial 2

  • Summary: This research is being done because it is not known how the timing of a reversible tracheostomy (a temporary tube that enters the airway through the front of the neck) relates to how brains recover after a severe stroke, and the body’s ability to return to pre-stroke activities. Preliminary studies suggest it could be beneficial to perform a reversible tracheostomy procedure earlier than is usually done, as opposed to waiting before performing the procedure. 

    Investigator: Deepak Nair

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT02880878

    Contact: Judi Beck, 309-624-3240, Judith.M.Beck@osfhealthcare.org

  • ARAMIS - Management of Acute Stroke Patients on Treatment With Novel Oral Anticoagulants: Addressing Real-world Anticoagulant Management Issues in Stroke Registry

  • Summary: This registry is designed to provide important and timely insight into the management of acute stroke patients who are on novel oral anticoagulants in community practice.

    Investigator: David Wang

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    ClinicalTrials.gov: NCT02478177

    Contact: Judi Beck, 309-624-3240, Judith.M.Beck@osfhealthcare.org

  • What are the characteristics of survivors and caregivers attending stroke camp?

  • Summary: This study is a descriptive survey of adult stroke survivors and stroke caregivers who have attended stroke camp to obtain demographic characteristics and effects of the stroke camp on perceptions of depression, isolation, and loneliness.

    Investigator: Maureen Mathews

    Location: OSF HealthCare Saint Francis Medical Center, Peoria, IL

    Contact: Judi Beck, 309-624-3240, Judith.M.Beck@osfhealthcare.org