Sister M. Frances Krasse and a handful of Sisters of the Fraternal Order of St. Francis arrive in Peoria to set up a hospital in a house on Adams Street.

St. Francis Hospital School of Nursing opens to Sisters only. Thirteen years later, the school accepts applications from lay students.

A first-of-its-kind surgery to repair the aorta of a 3-month-old is performed in Peoria

OSF Saint Francis opens the first intensive care unit in Peoria.

An OSF crew completes the first helicopter transport of a premature newborn in the nation.

OSF Saint Francis is designated as the region’s trauma center.

The first open heart surgery at OSF Saint Francis is performed.

The first CT scan equipment in Peoria arrives at OSF Saint Francis.

OSF launches the children’s heart surgery program.

OSF Saint Francis makes national news for lifesaving treatment of the smallest patient – a premature baby weighing 1 lb., 12 oz.

The first use of MRI in central Illinois occurs at OSF Saint Francis.

The first kidney transplant in central Illinois is completed at OSF Saint Francis.

Peoria’s first heart transplant is performed at OSF Saint Francis.

Peoria’s first breast center opens at OSF Center for Health on Route 91.

Children’s Hospital of Illinois is formed at OSF Saint Francis.

OSF PromptCare starts seeing patients.

Sisters' Community Health Care Center is opened to help the underserved in the south side of Peoria.

The Jim and Trudy Maloof St. Jude clinic is relocated to OSF Children’s Hospital of Illinois.  

The first procedure to use stent grafts for an aortic aneurysm in central Illinois is performed at OSF Saint Francis.

On February 15, a groundbreaking is held for RecPlex – later named RiverPlex – a joint effort between OSF Saint Francis and the Peoria Park District.

The first transmyocardial revascularization, or TMR, in central Illinois is performed.

Gamma Knife, a groundbreaking technology for neurosurgeons and radiation oncologists, is installed at OSF Saint Francis.
The OSF Center for Health opens in north Peoria. It contains ambulatory surgery, lab, imaging, radiology, an OSF PromptCare, women's services and doctors' offices. 

An OSF surgeon performs the area's first pancreas transplant and the first kidney-pancreas transplant two days later.

Robotic-assisted surgery is introduced.

Ten days of events surround the opening of the new OSF HealthCare Children's Hospital of Illinois and OSF Saint Francis building. It’s the largest construction project in the history of Peoria up to this point.

Jump Simulation is established in partnership with the University of Illinois College of Medicine Peoria.

OSF Center for Health in Pekin opens its doors to patients.

OSF takes over the former LR Nelson Company building and renames it the Franciscan Prairie building.

Almost Home Kids – a division of OSF Children’s Hospital – opens its doors to families needing respite care or transitional care for their children with complex medical needs.

OSF OnCall extends revolutionary digital health services and 24/7 virtual care.

OSF Center for Health on Knoxville Avenue opens in the former Cub Foods building near the OSF Saint Francis campus.

OSF HealthCare holds a groundbreaking for OSF HealthCare Cancer Institute. The location will be just the second center in Illinois offering proton beam therapy to treat patients, reducing treatment times, side effects and disruption in the lives of patients and caregivers.

The new Ministry Headquarters in downtown Peoria opens for business in January.

OSF HealthCare opens the OSF Transitional Care Hospital in downtown Peoria under a new venture with Kindred Hospitals.

OSF HealthCare Cancer Institute opens its doors and brings innovative, cutting-edge technology to Peoria, including the region's only proton beam therapy, Phase-1 clinical trials and comprehensive support services.