Nano Knife

NanoKnife: Exciting potential in cancer treatment

Time is precious.

We even monetize time, charging for services or getting paid at rates per hour, day, week, month or year. In the end, though, people tend to value time over money. In fact, studies show that people who value time over money are happier.

That’s one reason why medical advances are such big deals. These breakthroughs help extend the time we have to spend with loved ones, doing things we enjoy.

One such technological advance in the fight against cancer is the NanoKnife System®, which arrived at OSF HealthCare Saint Francis Medical Center in Peoria, Illinois, this winter.

Survival time after diagnosis doubles

Pancreatic cancer is difficult to diagnose in its early stages when it’s more treatable. By Stage 3, while it has not spread to other organs, it is often too advanced to be able to remove surgically. Average life expectancy after diagnosis of Stage 3 pancreatic cancer is about nine to 15 months, in part depending on what treatment options are feasible.

The NanoKnife is changing that.

“Thus far, we’re seeing studies that using the NanoKnife virtually doubles life expectancy for pancreatic cancer patients,” said Tom Cox, director of Radiology, Radiation Oncology and OSF Cancer Services at OSF Saint Francis. “On average, we’ve been told life expectancy for these patients is around two years.

“From my perspective, what we are trying to do is give people options. Patients want it straight from providers: ‘Lay out my options and let’s decide what direction to go.’ This is another option we can show and give them another chance to live longer – and maybe the chance to live a lot longer.”

Limits on pancreatic cancer treatment

Thermal ablation – a menu of procedures that treat cancer by using probes to apply extreme heat or cold – is a technique that can be used for tumors that cannot be surgically removed. It kills not only cancerous cells but also healthy cells in adjacent structures. Some organs can tolerate this collateral damage, but others, such as the duodenum and the common bile duct, which are around the pancreas, cannot. The same type of damage to healthy cells occurs with radiation.

Nano Knife computer controller

“In regard to thermal ablative therapies, the pancreas is an organ that doesn’t like to be messed with,” said Robert King, MD, director of Non-Invasive Vascular Imaging for Central Illinois Radiological Associates in Peoria.

The pancreas is located behind the stomach and tucked under the liver. It’s about six inches long, and its head is connected to the small intestine.

“Because the pancreas is high real estate and there are other major structures and vessels in the area, you can’t cut the cancer out in surgery unless you’ve diagnosed it relatively early,” said Sonia Orcutt, MD, medical director of Surgical Oncology for Peoria Surgical Group.

Kill cancer cells, save healthy cells

Dr. King and Dr. Orcutt are two of three physicians at OSF Saint Francis trained to use the NanoKnife System. The third is Chandler Wilfong, MD, of OSF Medical Group – Surgery.

The NanoKnife probes are placed around the tumor with image guidance. The probes then deliver a series of high voltage pulses to cancerous cells. But rather than burning or freezing, like the thermal ablation probes, the NanoKnife pulses punch holes through the cell membranes.

“That disrupts the equilibrium of the cell with its surrounding area, and the body says that cell needs to be destroyed because its membrane has been damaged,” Tom said. “The body in essence is ridding the tumor on its own, recognizing there has been damage to all of the cancerous cells.”

The key is being able to target the diseased cells and minimize the peripheral damage.

“We can place the probes next to an artery or vein and ablate cancer tissue while leaving the arteries and veins intact,” Dr. King said. “That gives us a huge advantage.”

Exciting potential

Nine to 15 months; basically a year, give or take. That might not sound like much, but think about all the living that can be packed into that amount of time. One more holiday. One more round of family birthdays. A graduation. A wedding. The birth of a child or grandchild.

Studies show an average two-year survival rate for pancreatic cancer patients who have undergone NanoKnife procedures.

“And that average of two years is going to grow,” Tom said.

The NanoKnife System isn’t just for pancreatic cancer, either.

“We have a patient scheduled for soft tissue ablation of recurrent anal cancer,” Dr. King said. “We have some other cases, outside the pancreas; a couple of patients with liver cancer that look like good candidates. There is a multi-center trial going on now, hopefully to be completed this summer, that gives me hope that this technology may be a viable option to treat prostate cancer.”

The potential of the NanoKnife is great, according to Dr. Orcutt.

“It’s great,” she said, “to be on the front lines of something like this.”

Last Updated: January 25, 2022

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About Author: Kirk Wessler

After being a writer for OSF HealthCare for three years, Kirk Wessler retired in January 2022. A Peoria native and graduate of Bradley University, Kirk's experience included working for newspapers in Missouri, Texas and the Peoria Journal Star.

Kirk and his wife, Mary Frances, have five sons, four daughters-in-law and nine grandchildren. Kirk plans to spend his retirement on the golf course, mastering the guitar and traveling.

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Categories: Cancer