PCR vs. rapid COVID-19 test: What’s the difference?

The message is clear: Get tested, as it’s one of our best defenses against stopping the spread of COVID-19. What’s not so clear is which kind of COVID-19 test is the best.

Types of COVID-19 tests

Two types of COVID-19 tests are popular: the polymerase chain reaction (PCR) test and the antigen test, a.k.a. the rapid test. Both tests require a sample from the patient, usually a nasal swab.

PCR test

How it works

The PCR test takes a sample of ribonucleic acid (RNA) and “amplifies” it with the help of lab technologies. Amplifying RNA helps to make even small traces of the COVID-19 virus visible in the test sample. Even if you have a small trace of the virus in your system, the PCR test will detect it.

The PCR test doesn’t alter your genetic material – DNA – in any way, and your test provider isn’t able to do anything with your DNA besides tell if you’re positive with COVID-19.


“PCR tests are more reliable and accurate due to testing the specific genetic material of the virus, eliminating the interference from other viruses,” said Heather Seyko, a Laboratory Services manager for OSF HealthCare.


While a PCR test is the preferred method of detecting COVID-19, it’s not always the easiest test to get. PCR tests must be done by a health care provider, and they don’t produce immediate results, which means you may be waiting a few days to know if you’re positive or negative.

The Centers for Disease Control and Prevention notes while tests are best used early in the course of illness to diagnose COVID-19, they are not authorized to evaluate the duration of infectiousness. PCR tests can stay positive for weeks sometimes after you’ve had COVID. This is because the PCR test is so sensitive it can detect even dead virus.

Antigen test

How it works

The rapid test, called an antigen test, checks for proteins that are found on the outside of the virus.

The antigen test mimics what antibodies do. Antibodies are the “good guys” that attach to the antigen protein (the “bad guys”) and fight the virus. When you give your nasal swab sample, it’s put into a liquid and then onto a test strip.

The test strip acts like an antibody – if there are any COVID-19 antigen “bad guys” in your system, the molecules in the liquid will attach to those antigens, and a line will appear on the test strip. This means you’re positive for COVID-19. If there are no antigens detected in your system, the liquid doesn’t respond and no line will appear, often meaning you are negative for the virus.


  • Results in about 15 minutes
  • Easy enough to do on your own (There’s always a little room for user error, but as long as you closely follow the directions, anyone can test themselves with an antigen test.)
  • Helps slow the spread of contagious viruses like COVID-19 with quicker results


“Unlike the PCR test, the antigen test can only determine if you have an active virus in your body. The rapid test can’t detect small amounts of the virus or asymptomatic cases as accurately as the PCR test can,” Heather said.

The rapid test is less accurate and there is a greater chance for a false negative. Plus, the test will only pick up if the virus is active in your body, meaning asymptomatic cases – when someone doesn’t have any symptoms – are harder to identify with the antigen test.

Choosing which test to get

Experiencing symptoms?

> Get tested for COVID-19

If you’re visiting a health care provider to get tested, it’s likely you won’t get to choose which test you get. This is for a few reasons. First, it could just be a matter of what test is readily available or in greater supply. Second, tests are chosen based on probability of having the virus.

“PCR would be chosen where there is a low likelihood of having the virus, but we want to be certain the patient doesn’t have it. Antigen would be chosen if there is a high probability the patient has the virus (i.e. is experiencing symptoms), and we need to screen the patient as positive or negative,” Heather said.

Getting tested is an important part of slowing the spread of COVID-19. With more accurate results, PCR tests are the preferred way to go, but antigen tests work for rapid results, as well.

Last Updated: August 1, 2022

About Author: Katie Faley

Katie Faley is a Writing Coordinator for OSF HealthCare. She graduated from Illinois State University with a degree in English Studies. Before joining OSF HealthCare in 2021, she worked in magazine editing, digital marketing and freelance writing.
Katie is often found listening to ‘60s folk music, deciding on a new skill to learn, losing track of time in a library or spending time with her family and friends.

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Categories: COVID-19